Radicate Selamectin 12% Liquid Spot On is a topical parasiticide for dogs weighing 20-40kg. It contains selamectin, which is effective against fleas, ticks, ear mites, biting lice, and sarcoptic mange. It also prevents heartworm disease and treats adult intestinal roundworms. The liquid is applied to the skin, typically at the back of the neck. Selamectin works by interfering with the nerve and muscle function of parasites, leading to their paralysis or death. It is important to use the correct dosage based on the dog's weight.

The medicine prevents the immune system in releasing chemicals known as prostaglandins which are responsible for the symptoms to cause the body's response to arthritis, which makes it useful for reduction of joint pain, difficulty in moving, with other symptoms associated with arthritis.

Selamectin is used to kill adult fleas and ear mites in dogs and cats. It also kills Sarcoptes scabiei, a mite that causes sarcoptic mange (scabies), certain ticks in dogs, and hookworms and roundworms in cats. Selamectin is also used to prevent heartworm disease and flea infestation in dogs and cats.